Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer.The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high
With critical limb ischemia (CLI) being a multi-factorial disease, it is becoming evident that gene therapy with a multiple mz7lh3t8hmlt bio-functional growth factor could achieve better therapeutic outcomes.Cytochrome P450 epoxygenase-2J2 (CYP2J2) and its catalytic products epoxyeicosatrienoic acids (EETs) exhibit pleiotropic biological activities
Sea barley Hordeum marinum is an important germplasm resource.However, the origin of this tetraploid H.marinum st patricks day teacher gift subsp.gussoneanum is still unclear, which has caused great perplexity to the exploration and utilization of germplasm resources.We used two single-copy nuclear genes, thioredoxin-like gene (TRX) and waxy1 gene
Fatigue failure is a critical concern for offshore wind turbines (OWTs).In cold-region seas, the presence of sea ice necesitates the consideration of ice loads in the design of OWTs.This study focuses on the NREL 5MW monopile wind turbine and proposes a numerical analysis framework for asesing fatigue damage under wind-ice coupling effects.Aerodyna